Alternative to the typical slipknot - More comfortable, less bulky, more secure

Very much this. Some are downright soapy slick and the normal way never stayed put with them. Angel hair particularly hated the typical loop-tie method.
Toxic dragons are another good example of a string that likes special treatment. The trade off is insane long life and snug, secure, minimal, and perfect knot placement for least digging or distraction.